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Peptide record

TPDB93134

CF-Penetratin(desMet) Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB93134
CF-Penetratin(desMet)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with CF
Sequence
RQIKIWFQNRRKWKK
Physicochemical Analysis
C99H159N33O19
ADCEGHLMPSTYV
K
2115.56
12.72
7
0
5
+7
2.52
-1.973
52.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
519.96
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C99H159N33O19
2115.56
12.72
+7
2.52
-1.973
Free
L
Amphipathic
Linear
Conjugated with CF
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And MDA-MB-234

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Pentaglutamylated derivative of Methotrexate (MTX-Glu5)
Internalisation of CF labelled octaarginine was higher than that of CF-Penetratin(desMet) on both cells
In vitro
CCCCCCTTCSTTSCC
Additional Detail Fields 1 fields
CCCCCCTTCSTTSCC