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Peptide record

TPDB93121

CPP Cell-penetrating Peptides Tumor-homing Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB93121
CPP
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 15-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Chemical: poly(N-vinylcaprolactam) (PNVCL)-chitosan (CS) via amide bond.
Sequence
RLYMRYYSPTTRRYG
Physicochemical Analysis
C89H135N27O23S1
ANDCEQHIKFWV
RY
1983.28
10.58
4
0
6
+4
-0.44
-1.447
26.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5960
300.51
7
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
1
S
2
T
0
W
4
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 1 T: 2 W: 0 Y: 4 V: 0
Chemical Descriptors
15
C89H135N27O23S1
1983.28
10.58
+4
-0.44
-1.447
Free
poly(N-vinylcaprolactam) (PNVCL)-chitosan (CS) via amide bond.
L
Amphiphilic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And HUVEC Cells

Assay & Model

Adult Wistar rats (180–220 g) and female nude mice (16–22 g)
Adult Wistar rats (180–220 g) and female nude mice (16–22 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
Doxorubicin (DOX) loaded nanoparticles (NPs)
In, MCF-7 cells treated with CPP-CS-co-PNVCL1@ DOX NPs exhibited ca. 4.5-fold and 3.0-fold stronger red fluorescence than those exposed to free DOX and CS-co-PNVCL1@DOX NPs. but No significant differences between the treatment groups were seen with the HUVEC cells
In vitro and in vivo
CCTTCSSCC
Additional Detail Fields 1 fields
CCTTCSSCC