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Peptide record

TPDB93118

SCPP-PS Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB93118
SCPP-PS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC-labelled polymersomes
Sequence
RLWMRWYSPRTRAYGC
Physicochemical Analysis
C95H140N30O21S2
NDEQHIKFV
R
2102.47
11.12
4
0
7
+4
-2.81
-0.994
30.63
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
13980
664.93
5
Residue Composition
number
1
A
4
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
1
S
1
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 1 T: 1 W: 2 Y: 2 V: 0
Chemical Descriptors
16
C95H140N30O21S2
2102.47
11.12
+4
-2.81
-0.994
Free
FITC-labelled polymersomes
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

H460 And A549 Lung Cancer Cells L929, MDA-MB-231, Hep 3B, And U87 Mg Cells

Assay & Model

A549 tumor xenografts [female nude mice (18–22 g)]
A549 tumor xenografts [female nude mice (18–22 g)]

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Methotrexate disodium (MTX)
Cytoplasm
2.2–3.3 fold more uptake of FITC-MTX-SCPP-PS by H460 and A549 lung cancer cells than by other cells such as L929, MDA-MB-231, Hep 3B, and U87 MG cells . And 2.1- and 6.4-fold higher FITC fluorescence than FITC-MTX-PS and free FITC-MTX in A549 cells.
Dynamin-dependent and clathrin/macropinocytosis-independent pathway direct transduction as well as endocytosis
In vitro and in vivo
CCCCCSSSCSSCCSCC
Additional Detail Fields 1 fields
CCCCCSSSCSSCCSCC