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Peptide record

TPDB93117

CPP33 Cell-penetrating Peptides Tumor-homing Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB93117
CPP33
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 15-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: ZIF-90 and Polyethylene glycol (PEG)-conjugated Nanoparticle
Sequence
RLWMRWYSPRTRAYG
Physicochemical Analysis
C92H135N29O20S1
NDCEQHIKFV
R
1999.33
11.94
4
0
7
+4
-2.57
-1.227
32.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
13980
699.24
4
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
1
S
1
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 1 T: 1 W: 2 Y: 2 V: 0
Chemical Descriptors
15
C92H135N29O20S1
1999.33
11.94
+4
-2.57
-1.227
Free
ZIF-90 and Polyethylene glycol (PEG)-conjugated Nanoparticle
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hepg2, A549, MDA-MB-231, And Ht-29 Cells

Assay & Model

BALB/c nude mice (8–10-weeks old, 20 g)
BALB/c nude mice (8–10-weeks old, 20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
oridonin (ORI), survivin siRNA
Cytoplasm
PEG-CPP33@siRNA@ZIF-90, the drug-loaded nanoparticles showed the strongest fluorescence intensity in the A549 cells after modification with PEG-CPP33.
Clathrin/microcytosis/caveo-independent pathways
In vitro and in vivo