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Peptide record

TPDB93116

Cys-CPP33 Cell-penetrating Peptides Tumor-homing Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB93116
Cys-CPP33
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 15-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Anti-CA IX antibody conjugated liposomes N-terminal: Addition of Cysteine
Sequence
RLWMRWYSPRTRAYG
Physicochemical Analysis
C92H135N29O20S1
NDCEQHIKFV
R
1999.33
11.94
4
0
7
+4
-2.57
-1.227
32.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
13980
699.24
4
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
1
S
1
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 1 T: 1 W: 2 Y: 2 V: 0
Chemical Descriptors
15
C92H135N29O20S1
1999.33
11.94
+4
-2.57
-1.227
Free
Anti-CA IX antibody conjugated liposomes
L
Linear
Addition of Cysteine
N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells 3 D Tumor Spheroids

Assay & Model

Orthotopic lung tumor-bearing mice model (Male BALB/c nu/nu mice (7–8 weeks old))
Orthotopic lung tumor-bearing mice model (Male BALB/c nu/nu mice (7–8 weeks old))

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Triptolide (TPL)
dl-lip penetrated more deeply into different layer of the spheroids as compared to non-modified liposomes, CA IX-lip, and CPP33-lip
In vitro and in vivo
CGGGGGHHHHGGGSCCCCC
Additional Detail Fields 1 fields
CGGGGGHHHHGGGSCCCCC