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Peptide record

TPDB93114

#2077 Blood-Brain Barrier Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93114
#2077
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 12-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: Conjugated with CF Via GGG Linker
Sequence
RLSSVDSDLSGC
Physicochemical Analysis
C48H83N15O21S1
ANEQHIKMFPTWY
S
1238.33
3.88
1
2
3
-1
2.51
-0.067
89.17
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
5
Residue Composition
number
0
A
1
R
0
N
2
D
1
C
0
E
0
Q
1
G
0
H
0
I
2
L
0
K
0
M
0
F
0
P
4
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 4 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C48H83N15O21S1
1238.33
3.88
-1
2.51
-0.067
Free
L
Linear
Conjugated with CF Via GGG Linker
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

hCMEC/D3 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
CF dye
#2077 and LNP peptides, showed significantly lower permeability than FD-4.
In vitro
CCSCCCTTCCSCCC
Additional Detail Fields 1 fields
CCSCCCTTCCSCCC