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Peptide record

TPDB93107

CPP Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB93107
CPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Liposomes
Sequence
RKKRRQRRRC
Physicochemical Analysis
C56H111N31O12S1
ANDEGHILMFPSTWYV
R
1442.76
12.71
8
0
0
+8
7.18
-3.580
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C56H111N31O12S1
1442.76
12.71
+8
7.18
-3.580
Free
Liposomes
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Assay & Model

Male BALB/c nude mice of 20 ± 2 g
Male BALB/c nude mice of 20 ± 2 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Epirubicin and Dioscin
Cellular Membrane And The Nuclei
cellular uptake of fluorescent probe slightly enhanced after CPP (mmp) modified epirubicin plus dioscin liposomes were treated with the increasing concentration of MMP2 enzymes.
In vitro and in vivo
CCEEETTEEEC
Additional Detail Fields 1 fields
CCEEETTEEEC