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Peptide record

TPDB93103

PTD Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB93103
PTD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
N-terminal: GFP
Sequence
RHIKIWFQNRRMKWKK
Physicochemical Analysis
C105H167N35O19S1
ADCEGLPSTYV
K
2255.76
12.72
8
0
6
+7
2.67
-1.712
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
487.64
2
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
1
Q
0
G
1
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C105H167N35O19S1
2255.76
12.72
+7
2.67
-1.712
Free
L
Cationic
Linear
GFP
N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat Cell, Bcbl1, Macrophage Cells (Mø), Mast Cells And Non-Immune Modulatory Cells,293T , Panc-1 And Hpde Cells

Assay & Model

Eight-week-old female C57BL/6 mice
Eight-week-old female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
GFP protein
Nucleus
PTD-GFP, no uptake (0%) was observed in any other cell type except kidney and pancreatic cells.
In vitro and in vivo
CCCCCCSCCSSSSCC
Additional Detail Fields 1 fields
CCCCCCSCCSSSSCC