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Peptide record

TPDB93096

SynB1 Blood-Brain Barrier Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB93096
SynB1
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 18-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Elastin-like polypeptide (ELP)
Sequence
RGGRLSYSRRRFSTSTGR
Physicochemical Analysis
C86H146N36O26
ANDCEQHIKMPWV
R
2100.33
12.70
6
0
3
+6
3.06
-1.528
21.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
70.94
7
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
1
L
0
K
0
M
1
F
0
P
4
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 4 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
18
C86H146N36O26
2100.33
12.70
+6
3.06
-1.528
Free
Elastin-like polypeptide (ELP)
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

MDA-MB231 triple negative human breast cancer cell line xenografts in nude mice,
MDA-MB231 triple negative human breast cancer cell line xenografts in nude mice,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Doxorubicin (DOXO-EMCH)
Tumors showed a 2-fold higher uptake when treated with SynB1-ELP1-DOXO compared to free dox after 2hr incubation.
In vivo
CCSCCTTSSSCC
Additional Detail Fields 1 fields
CCSCCTTSSSCC