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Peptide record

TPDB93087

QL Blood-Brain Barrier Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB93087
QL
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CellPPD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 5-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict, CellPPD, CPPsite3.0, and other sources, with an available 3D structural model.
Chemical: DiI-labelled liposomes modified with transferrin (Tf)
Sequence
QLPVM
Physicochemical Analysis
C26H46N6O7S1
ARNDCEGHIKFSTWY
QLMPV
586.75
6.02
0
0
3
-0
0.31
0.960
136.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C26H46N6O7S1
586.75
6.02
-0
0.31
0.960
Free
DiI-labelled liposomes modified with transferrin (Tf)
L
Hydrophobic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3, Glial And Primary Neuronal Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Protein derived
plasmid DNA
The uptake of all liposomal formulations increased on average from 33% to 71% in bEnd.3 cells, 35% to 66% in glial cells and In primary neuronal cells from 33% to 65%, waereobserved after 1 hour and 4 hours of incubation.
Clathrin- and Caveolae-dependent endocytosis and macropinocytosis
In vitro
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC