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Peptide record

TPDB93080

Mem-QGR-[WK]3-FAM Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB93080
Mem-QGR-[WK]3-FAM
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Carboxyfluorescein Labelled N-terminal: Memantine Attached
Sequence
QGRWKWKWK
Physicochemical Analysis
C64H91N19O11
ANDCEHILMFPSTYV
KW
1302.55
11.73
4
0
3
+4
-1.18
-2.533
0.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
16500
1266.75
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
9
C64H91N19O11
1302.55
11.73
+4
-1.18
-2.533
Carboxyfluorescein Labelled
L
Amphiphilic
Linear
Memantine Attached
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
5(6)-FAM dye
Around The Cell Membrane
Reduction in cellular uptake with C-terminal modification
In vitro
CCCSSCCCC
Additional Detail Fields 1 fields
CCCSSCCCC