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Peptide record

TPDB93067

RBDwt-S19-TAT Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB93067
RBDwt-S19-TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: wild type viral RNA-binding domains (RBDwt)
Sequence
PFVIGAGVLGALGTGIGGIYGRKKRRQRRR
Physicochemical Analysis
C142H245N51O34
NDCEHMSW
G
3210.83
12.71
8
0
11
+8
3.77
-0.307
91.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
46.41
3
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
0
E
1
Q
8
G
0
H
3
I
2
L
2
K
0
M
1
F
1
P
0
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 8 H: 0 I: 3 L: 2 K: 2 M: 0 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
30
C142H245N51O34
3210.83
12.71
+8
3.77
-0.307
Free
wild type viral RNA-binding domains (RBDwt)
L
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And Lncap Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
Cy3-labelled siRNA
Cytoplasm
Higher uptake of siRNA/RBDmut-S19-TAT compared to siRNA/RBDwt-S19-TAT
Macropinocytosis
In vitro
CCIIIIIHHHHTSSSTTTTCCTTGGGTCCC
Additional Detail Fields 1 fields
CCIIIIIHHHHTSSSTTTTCCTTGGGTCCC