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Peptide record

TPDB93056

CPP Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB93056
CPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Truncated hepatitis B core antigen (tHBcAg)
Sequence
NRPDSAQFWLHH
Physicochemical Analysis
C68H94N22O18
CEGIKMTYV
H
1507.63
8.00
3
1
4
+0
1.83
-1.358
40.83
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5500
364.81
3
Residue Composition
number
1
A
1
R
1
N
1
D
0
C
0
E
1
Q
0
G
2
H
0
I
1
L
0
K
0
M
1
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 2 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C68H94N22O18
1507.63
8.00
+0
1.83
-1.358
Free
Truncated hepatitis B core antigen (tHBcAg)
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A431 And Nhdf Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC-labelled nanoparticles (VLNPs)
free FITC-NRPDSAQFWLHH peptide was able to internalise A431 cells compared with NHDF cells, where no significant fuorescent signal was observed.
Clathrin mediated endocytosis via epithelial growth factor receptor (EGFr)
In vitro
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC