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Peptide record

TPDB93034

A2A (AA3H) AA3H Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB93034
A2A (AA3H) AA3H
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
MASIWVGHRG
Physicochemical Analysis
C49H76N16O12S1
NDCEQLKFPTY
G
1113.30
11.05
2
0
5
+1
-0.57
0.220
78.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
494.03
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
1
I
0
L
0
K
1
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 1 L: 0 K: 0 M: 1 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
10
C49H76N16O12S1
1113.30
11.05
+1
-0.57
0.220
Free
L
Linear
Conjugated with FITC
N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Cytoplasm And Lysosome Or Plasma Membrane
Intracellular translocation uptake efficiency at 1μM in the order of AA3H> AA5H> AA8H> AA13H> AA4H
Clathrin- and Caveolae-dependent endocytosis and macropinocytosis
In vitro
CCSCCSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
FITC dye
In vitro
CCSCCSSCC
Additional Detail Fields 1 fields
CCSCCSSCC