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Peptide record

TPDB93032

DEN-NRTN-17 (Compound 4) Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB93032
DEN-NRTN-17 (Compound 4)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: poly-L-lysine dendron
Sequence
LRRLRQRRRLRRERVRA
Physicochemical Analysis
C96H184N48O21
NDCGHIKMFPSTWY
R
2346.83
13.00
10
1
5
+9
8.92
-2.035
91.76
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
10
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
0
I
3
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 10 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C96H184N48O21
2346.83
13.00
+9
8.92
-2.035
Free
L
Cationic
Linear
poly-L-lysine dendron
N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
YOYO-1 labeled pDNA
Cytoplasm
Showed a significant increase (2-10 fold increase) in comparison to Compound 3
Non-endocytic mechanism
In vitro
CCSSSCCC
Additional Detail Fields 1 fields
CCSSSCCC