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Peptide record

TPDB93029

AEP-dendron Blood-Brain Barrier Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB93029
AEP-dendron
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 10-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: AEP attached at N-terminal
Sequence
LRKLRKRLLR
Physicochemical Analysis
C60H118N24O11
ANDCEQGHIMFPSTWYV
RL
1351.75
12.88
6
0
4
+6
2.98
-1.060
156.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C60H118N24O11
1351.75
12.88
+6
2.98
-1.060
Linear
AEP attached at N-terminal
Similarity
Cationic
LeuArgLysLeuArgLysArgLeuLeuArg
N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

bEnd.3 Cell Line

Assay & Model

50000 cells per cm square
Laser Scanning Confocal Microscopy (LSCM)
LSCM showed the cellular uptake of the RMT-competent AEP-dendron.
Origin/Source

Source & Reference

NA
B3Pdb

Other

ApoE protein
Successful synthesis of dendronised carrier systems with the potential to act as carriers for improv
Receptor-mediated transcytosis
Comined