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Peptide record

TPDB93012

EB1-Cys Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB93012
EB1-Cys
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
Chemical: Cysteine modification
Sequence
LIRLWSHLIHIWFQNRRLKWKKKC
Physicochemical Analysis
C153H240N46O28S1
ADEGMPTYV
LK
3203.94
12.16
9
0
11
+7
-0.65
-0.500
113.75
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
16500
514.99
4
Residue Composition
number
0
A
3
R
1
N
0
D
1
C
0
E
1
Q
0
G
2
H
3
I
4
L
4
K
0
M
1
F
0
P
1
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 2 I: 3 L: 4 K: 4 M: 0 F: 1 P: 0 S: 1 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
24
C153H240N46O28S1
3203.94
12.16
+7
-0.65
-0.500
Cysteine modification
L
Linear
N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HEK293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nucleic acid (Plasmid DNA)
Cytoplasm
C-terminal cysteine modification did not significantly improve its function under endosomolytic conditions
Endocytosis
In vitro
CCTTTSCCSCCCCCCCSCSSCC
Additional Detail Fields 1 fields
CCTTTSCCSCCCCCCCSCSSCC