TPDB

3D PDB MODEL

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TPDB ID TPDB93003

Peptide_Name

Xentry (compound 56) Xentry (compound 62) Xentry (compound 68)

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Acylation

Sequence

LCLRPVG-NH2

FASTA

>TPDB93003|Cell-penetrating Peptides|length=7
LCLRPVG-NH2

Formula C33H60N10O8S1

Absent Amino Acids ANDEQHIKMFSTWY

Common Amino Acids L

Mass 756.96

PI 9.01

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index -0.02

Hydrophobicity 1.114

Aliphatic Index 152.86

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

1

R

0

N

0

D

1

C

0

E

0

Q

1

G

0

H

0

I

2

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

7

Formula

C33H60N10O8S1

Mass

756.96

PI

9.01

Net Charge

+1

Boman Index

-0.02

Hydrophobicity

1.114

C_terminal_Modification

Amidation

Chirality

L

Linearity

Linear

N_terminal_Modification

Acylation

SMILES

N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Human THP-1 Monocyte-Like Cell Line

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L

Cargo Type Linear 9mer 3,5 difluorophenylglycine

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCHHHHTCCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Human THP-1 Monocyte-Like Cell Line

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Cargo Type 7-mer cyclic lactam

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCHHHHTCCC

Evidence 3 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Human THP-1 Monocyte-Like Cell Line

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Cargo Type Triazole

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCHHHHTCCC

DSSP_Secondary_Structure

CCCCHHHHTCCC