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Peptide record

TPDB93000

BBBpS_1 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB93000
BBBpS_1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
KYKGAIIGNIK-NH2
Physicochemical Analysis
C56H97N15O14
RDCEQHLMFPSTWV
IK
1204.48
10.46
3
0
5
+3
1.37
-0.182
115.45
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
123.71
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C56H97N15O14
1204.48
10.46
+3
1.37
-0.182
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hebc-5I, Hs68, HeLa, MDA-MB-231 And Hek-293 Cells

Assay & Model

7-weeks old CD1 female mice
7-weeks old CD1 female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
CF dye and Ga-radiolabed for in-vivo
Translocation = 61.4±2.3%
In vitro and in vivo
CCCCC
Additional Detail Fields 1 fields
CCCCC