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Peptide record

TPDB92999

MTpl-1 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB92999
MTpl-1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
KWSFRVSYRGISYRRSRGK
Physicochemical Analysis
C107H169N37O26
ANDCEQHLMPT
R
2389.75
12.24
7
0
6
+7
1.47
-1.384
35.79
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8480
354.85
6
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
0
L
2
K
0
M
1
F
0
P
4
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 2 M: 0 F: 1 P: 0 S: 4 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
19
C107H169N37O26
2389.75
12.24
+7
1.47
-1.384
Free
L
Cationic
Linear
Conjugated with FITC
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells , Triticum Aestivum Protoplasts, Root Tips, Coleoptiles And Hypocotyls

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FITC dye
Nucleus
Uptake of MTpl-1 was similar to that of Tpl
Direct membrane penetration
In vitro
CCCCCCCCCSCC
Additional Detail Fields 1 fields
CCCCCCCCCSCC