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Peptide record

TPDB92994

Pep-3 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB92994
Pep-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with FITC at C-terminal cysteamide N-terminal: Acetylation
Sequence
Ac-KWFETWFTEWPKKRK
Physicochemical Analysis
C104H145N25O22
ANDCQGHILMSYV
K
2097.45
10.55
5
2
5
+3
1.73
-1.813
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
786.67
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
2
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
2
F
1
P
0
S
2
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 2 P: 1 S: 0 T: 2 W: 3 Y: 0 V: 0
Chemical Descriptors
15
C104H145N25O22
2097.45
10.55
+3
1.73
-1.813
Conjugation with FITC at C-terminal cysteamide
L
Amphipathic
Linear
Acetylation
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Chimeric
Fluorophore (FITC)
Probably nucleus
Probably non-endocytic pathway
In vitro
CCSCCSSSSSCSSCC
Additional Detail Fields 1 fields
CCSCCSSSSSCSSCC