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Peptide record

TPDB92992

E162 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB92992
E162
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Conjugated with TAMRA Chemical: Lys side chain amine at the C-terminus
Sequence
KTVLLRKLLKLLVRKI
Physicochemical Analysis
C92H176N26O18
ANDCEQGHMFPSWY
L
1934.57
12.44
6
0
9
+6
2.19
0.650
206.88
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
6
L
4
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 6 K: 4 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
16
C92H176N26O18
1934.57
12.44
+6
2.19
0.650
Conjugated with TAMRA
Lys side chain amine at the C-terminus
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

By-2 Cells Leaves Of Nicotiana Benthamiana, Arabidopsis Thaliana, Tomato (Solanum Lycopersicum), Poplar (Hybrid Aspen Populus Tremula×Tremuloides Line T89), And Rice (Oryza Sativa).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
TAMRA dye
Nucleus
E162 showed significantly greater efficiencies than BP100.
In vitro
CCCTHHHHHHHHHHTC
Additional Detail Fields 1 fields
CCCTHHHHHHHHHHTC