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Peptide record

TPDB92991

RDP(rabies virus derived peptide) Blood-Brain Barrier Cell-penetrating Peptides standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB92991
RDP(rabies virus derived peptide)
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 39-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
Chemical: Targeting ligand mannose (MAN)
Sequence
KSVRTWNEIIPSKGCLRVGGRCHPHVNGGGRRRRRRRRR
Physicochemical Analysis
C191H332N84O47S2
ADQMFY
R
4621.39
12.70
16
1
7
+13
14.54
-1.464
52.31
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5625
121.72
7
Residue Composition
number
0
A
12
R
2
N
0
D
2
C
1
E
0
Q
6
G
2
H
2
I
1
L
2
K
0
M
0
F
2
P
2
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 12 N: 2 D: 0 C: 2 E: 1 Q: 0 G: 6 H: 2 I: 2 L: 1 K: 2 M: 0 F: 0 P: 2 S: 2 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
39
C191H332N84O47S2
4621.39
12.70
+13
14.54
-1.464
Free
Targeting ligand mannose (MAN)
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Primary Neurons, bEnd.3 Cells, And Primary Astrocytes.

Assay & Model

Male and female C57BL/6 mice
Male and female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
pVGF/chitosan complex
RDPMAN functionalized liposomes demonstrated highest transfection efficiency in all the cell lines, which was ~2 fold greater than the single ligand modified liposomes.
In vitro and in vivo
CCCCCTTCCCCCTHHHHSTTTSSCCTTHHHHTTTTCC
Additional Detail Fields 1 fields
CCCCCTTCCCCCTHHHHSTTTSSCCTTHHHHTTTTCC