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Peptide record

TPDB92989

(K-R8) Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB92989
(K-R8)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with FITC-Labelled HPMA Copolymer
Sequence
KRRRRRRRR-NH2
Physicochemical Analysis
C54H110N34O10
ANDCEQGHILMFPSTWYV
R
1395.69
13.25
9
0
0
+9
7.47
-4.433
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C54H110N34O10
1395.69
13.25
+9
7.47
-4.433
Amidation
L
Cationic
Linear
Conjugated with FITC-Labelled HPMA Copolymer
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 And Sk-Ov-3 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Cy5-labeled-RAC1 siRNA
Cytosol, Nucleus and Endosomes
P-(R8)9.5-FITC efficiently deliver siRNA , while siRNA encapsulated within P-(R8)5.4-FITC and P-(R8)4-FITC or naked siRNA did not enter the cells
In vitro
CCCCCCCCCCCSCSCC
Additional Detail Fields 1 fields
CCCCCCCCCCCSCSCC