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Peptide record

TPDB92978

pepM Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB92978
pepM
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: Conjugation with rhodamine B
Sequence
KLFMALVAFLRFLTIPPTAGILKRWGTI
Physicochemical Analysis
C155H249N37O32S1
NDCEQHSY
L
3174.97
12.42
4
0
17
+4
-4.70
1.021
132.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
173.23
3
Residue Composition
number
3
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
5
L
2
K
1
M
3
F
2
P
0
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 5 K: 2 M: 1 F: 3 P: 2 S: 0 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
28
C155H249N37O32S1
3174.97
12.42
+4
-4.70
1.021
Free
L
Hydrophobic
Linear
Conjugation with rhodamine B
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HepG2, BHK and HEK cell lineages, astrocytes and PBMC

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
Nucleic acid (ssDNA oligonucleotide labelled with Alexa-488)
Cytosol
Translocates lipid membranes directly
In vitro
CCCTTGGGTSSCSSCCCSHHHHHHSSCC
Additional Detail Fields 1 fields
CCCTTGGGTSSCSSCCCSHHHHHHSSCC