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Peptide record

TPDB92968

LAH4 Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB92968
LAH4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
KKALLALALHHLAHLALHLALALKKAC
Physicochemical Analysis
C135H233N39O28S1
RNDEQGIMFPSTWYV
L
2882.64
10.55
8
0
18
+4
0.60
0.981
174.07
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
8
A
0
R
0
N
0
D
1
C
0
E
0
Q
0
G
4
H
0
I
10
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 10 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
27
C135H233N39O28S1
2882.64
10.55
+4
0.60
0.981
Free
L
Linear
Conjugated with FITC
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

hCMEC/D3, Hek293T , Ecs And Has

Assay & Model

C57BL/6 female mice at 5 weeks of age
C57BL/6 female mice at 5 weeks of age

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
FITC and AAV serotype 9 (AAV9) encoding GFP
GFP-expressing cells increased about 540% compared to AAV9 alone
Endocytosis
In vitro and in vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC