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Peptide record

TPDB92966

hPP10-E3 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB92966
hPP10-E3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: E3 domain
Sequence
KIPLPRFKLKCIFCKKRRKR
Physicochemical Analysis
C118H208N38O21S2
ANDEQGHMSTWYV
K
2559.31
12.02
10
0
6
+10
5.60
-0.870
78.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
125
4.88
2
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
2
I
2
L
6
K
0
M
2
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 6 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C118H208N38O21S2
2559.31
12.02
+10
5.60
-0.870
Free
E3 domain
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Gfp-Expressing Stable Caski Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
siGFP
Cytosol and Nucleus
hPP10-E3/siGFP complex treatment was able to efficiently silence the GFP expression
In vitro
CCSCCSSSSCCCCCSCCCCC
Additional Detail Fields 1 fields
CCSCCSSSSCCCCCSCCCCC