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Peptide record

TPDB92957

Cyt 5-13 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB92957
Cyt 5-13
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: N-terminal acylation of peptide with 6-carboxy-tetramethylrhodamine
Sequence
KGKKIFIMK-NH2
Physicochemical Analysis
C52H93N13O10S1
ARNDCEQHLPSTWYV
K
1092.45
11.00
4
0
4
+4
1.99
-0.256
86.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C52H93N13O10S1
1092.45
11.00
+4
1.99
-0.256
Amidation
L
Linear
N-terminal acylation of peptide with 6-carboxy-tetramethylrhodamine
N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U373MG cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (6-carboxy-tetramethylrhodamine)
Medium (40 fold uptake)
In vitro
CCCCSCCCC
Additional Detail Fields 1 fields
CCCCSCCCC