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Peptide record

TPDB92956

Pep-1 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB92956
Pep-1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and PerseuCPP, with an available 3D structural model.
N-terminal: EGF
Sequence
KETWWETWWTEWSQPKKRKV
Physicochemical Analysis
C130H183N33O32
ANDCGHILMFY
W
2720.09
10.16
5
3
6
+2
3.23
-1.945
14.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
1011.00
5
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
3
E
1
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
1
P
1
S
3
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 3 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 1 S: 1 T: 3 W: 5 Y: 0 V: 1
Chemical Descriptors
20
C130H183N33O32
2720.09
10.16
+2
3.23
-1.945
Free
L
Amphipathic
Linear
EGF
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

3T3 cells and sections of BALA/c mouse skin

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphipathic
Protein derived
Human epidermal growth factor (hEGF) and FITC dye
Most excellent delivering ability was observed with Pep-1, followed by TAT and AA3H.
In vitro and ex vivo