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Peptide record

TPDB92955

Pep1 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB92955
Pep1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Folic acid (FA) modified liposomes
Sequence
KETWWETWWTEWSQPKKKRKVC
Physicochemical Analysis
C139H200N36O34S1
ANDGHILMFY
KW
2951.40
10.05
6
3
6
+3
3.98
-1.832
13.18
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
931.76
6
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
3
E
1
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
1
P
1
S
3
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 3 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 1 T: 3 W: 5 Y: 0 V: 1
Chemical Descriptors
22
C139H200N36O34S1
2951.40
10.05
+3
3.98
-1.832
Free
Folic acid (FA) modified liposomes
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mbt2 And 5637 Bladder Cancer Cell Lines

Assay & Model

Female C3H/HeN mice
Female C3H/HeN mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Bacillus Calmette–Guérin cell wall skeleton (BCG-CWS)
Cytoplasm
In 5637 cells, an appreciable superiority of CWS-FPL relative to CWS-FL and CWS-PL was demonstrated, revealing a greater density of scattered dot-like fluorescence throughout the cytoplasm at 2 h.
Receptor mediated endocytosis
In vitro and in vivo
CCSSCCSSCC
Additional Detail Fields 1 fields
CCSSCCSSCC