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Peptide record

TPDB92953

Pep1 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB92953
Pep1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Addition of Cysteine
Sequence
KETWWETWWTEWSQPKKKRKVC
Physicochemical Analysis
C139H200N36O34S1
ANDGHILMFY
KW
2951.40
10.05
6
3
6
+3
3.98
-1.832
13.18
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
931.76
6
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
3
E
1
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
1
P
1
S
3
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 3 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 1 T: 3 W: 5 Y: 0 V: 1
Chemical Descriptors
22
C139H200N36O34S1
2951.40
10.05
+3
3.98
-1.832
Addition of Cysteine
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO Cells

Assay & Model

Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors
Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Indocyanine green (ICG)-labeled Lactosomes (A3B-type)
Endosomes and Lysosomes
EB1 > Pep1 > -CPP cellular uptake efficiency of CPP-modified lactosomes in CHO cells
In vitro and in vivo
CCSCGGGCTTTCCSCGGGSCCC
Additional Detail Fields 1 fields
CCSCGGGCTTTCCSCGGGSCCC