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Peptide record

TPDB92940

dot1l Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB92940
dot1l
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
KARKKKLNKKGRKMAGRKRGRPKK
Physicochemical Analysis
C122H234N50O26S1
DCEQHIFSTWYV
K
2849.58
13.02
15
0
4
+15
13.72
-2.437
24.58
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
5
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
1
L
10
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 5 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 10 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C122H234N50O26S1
2849.58
13.02
+15
13.72
-2.437
Free
L
Linear
Conjugated with FITC
N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C1OO1
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF7, Hepg2, B16, And Hsc-T6 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
pDNA and GFP protein
Cytosol
The penetration efficiency of Dot1l was weaker than hPP10, but significantly higher than that of TAT and MT23,
Direct translocation
In vitro
CCCCSSCCCCCCCCCCSSSCCSCC
Additional Detail Fields 1 fields
CCCCSSCCCCCCCCCCSSSCCSCC