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Peptide record

TPDB92936

IRQ Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB92936
IRQ
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 7-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Coupling to polyoxyethylene (40) steartae (SA-PEG2000)
Sequence
IRQRRRR
Physicochemical Analysis
C41H81N23O9
ANDCEGHLKMFPSTWYV
R
1040.24
13.00
5
0
1
+5
4.32
-3.071
55.71
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C41H81N23O9
1040.24
13.00
+5
4.32
-3.071
Free
Coupling to polyoxyethylene (40) steartae (SA-PEG2000)
L
Cationic
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2/HT29-MTX

Assay & Model

Male Sprague-Dawley rats
Male Sprague-Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nanoparticle [salmon calcitonin (sCT)-loaded SLNs (Solid Lipid Nanoparticle)]
IRQ modified SLNs showed better drug protection ability
Clathrin- and caveolin-mediated endocytosis
In vitro and in vivo
CBTTBCC
Additional Detail Fields 1 fields
CBTTBCC