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Peptide record

TPDB92935

RIPL Cell-penetrating Peptides Tumor-homing Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB92935
RIPL
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 16-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: Fmoc
Sequence
IPLVVPLRRRRRRRRC
Physicochemical Analysis
C89H168N40O17S1
ANDEQGHKMFSTWY
R
2102.63
12.88
8
0
5
+8
5.85
-1.013
109.38
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
8
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
1
I
2
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
16
C89H168N40O17S1
2102.63
12.88
+8
5.85
-1.013
Fmoc
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Homing, Penetrating

Source & Reference

TumorHoPe2.0
TumorHoPe2
RIPL peptide (IPLVVPLRRRRRRRRC)-conjugated liposomes for enhanced intracellular drug delivery to hepsin-expressing cancer cells
2014
Kang M H et al. Eur J Pharm Biopharm.2014 Aug 87(3):489-99

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Human prostate cancer cells (LNCaP, DU145 and PC3), ovarian carcinoma cells (SK- OV-3), breast cancer cells (MCF-7), human keratinocyte cells (HaCaT)
Synthetic
Maleimide-derivatized liposomal vesicles
Additional Detail Fields 2 fields
Maleimide-derivatized liposomal vesicles
Human prostate cancer cells (LNCaP, DU145 and PC3), ovarian carcinoma cells (SK- OV-3), breast cancer cells (MCF-7), human keratinocyte cells (HaCaT)