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Peptide record

TPDB92934

RIPL Cell-penetrating Peptides Tumor-homing Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB92934
RIPL
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 16-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: RIPL peptides is conjugated to maleimide-derivatized liposomal vesicles via the thiol-maleimide reaction
Sequence
IPLVVPLRRRRRRRRC
Physicochemical Analysis
C89H168N40O17S1
ANDEQGHKMFSTWY
R
2102.63
12.88
8
0
5
+8
5.85
-1.013
109.38
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
8
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
1
I
2
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
16
C89H168N40O17S1
2102.63
12.88
+8
5.85
-1.013
Free
RIPL peptides is conjugated to maleimide-derivatized liposomal vesicles via the thiol-maleimide reaction
L
Cationic
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

LNCaP, SK-OV-3, and MCF-7 as Hpn-expressing cells, DU-145, PC-3, and HaCaT as Hpn-non-expressing cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
Fluorophore (FITC)
Cytoplasm
Increased from 20 to 70 fold compared to FITC dextran
Endocytic pathway
In vitro
CTTTCCCTTTGGGTCC
Additional Detail Fields 1 fields
CTTTCCCTTTGGGTCC