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Peptide record

TPDB92927

BBBpS_5 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92927
BBBpS_5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
HIQLSPFSQSWR-NH2
Physicochemical Analysis
C68H100N20O18
ANDCEGKMTYV
S
1485.67
11.05
2
0
4
+1
-0.08
-0.708
65.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5500
370.20
5
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
2
Q
0
G
1
H
1
I
1
L
0
K
0
M
1
F
1
P
3
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 1 L: 1 K: 0 M: 0 F: 1 P: 1 S: 3 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C68H100N20O18
1485.67
11.05
+1
-0.08
-0.708
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hebc-5I, Hs68, HeLa, MDA-MB-231 And Hek-293 Cells

Assay & Model

7-weeks old CD1 female mice
7-weeks old CD1 female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
CF dye and Ga-radiolabed for in-vivo
Translocation =53.0±4.7%. Showed the highest internalization (RFI>20.0).
In vitro and in vivo
CCCSSCCCCCC
Additional Detail Fields 1 fields
CCCSSCCCCCC