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Peptide record

TPDB92924

NF71 (H4-C18) NF71 Cell-penetrating Peptides modified_plain modified
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92924
NF71 (H4-C18) NF71
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 21-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Stearoylation
Sequence
HHYHHGOILLKALKALAKAIL-NH2
Physicochemical Analysis
C107H175N31O22
RNDCEQMFPSTWV
L
2247.76
10.46
7
0
12
+3
1.78
0.429
149.05
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
66.29
1
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
4
H
2
I
5
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 4 I: 2 L: 5 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C107H175N31O22
2247.76
10.46
+3
1.78
0.429
Amidation
Modified
Amphipathic
Linear
Stearoylation
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87-Luc Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified Amphipathic
Synthetic
siRNA (GFP and Luc)
H4-C18/siRNA shows lowest detected GFP signal
In vitro
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear Modified Amphipathic
Synthetic
Luciferase (Luc) gene from mRNA or pDNA
In vitro
CCCGGGCCCSSSSCCSSCSSSSTTTTC
Additional Detail Fields 1 fields
CCCGGGCCCSSSSCCSSCSSSSTTTTC