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Peptide record

TPDB92921

STR-HK Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB92921
STR-HK
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Stearylation
Sequence
HHHPKPKRKV-NH2
Physicochemical Analysis
C57H94N22O11
ANDCEQGILMFSTWY
HK
1263.51
11.73
7
0
1
+4
7.63
-2.480
29.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
3
H
0
I
0
L
3
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 0 K: 3 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
10
C57H94N22O11
1263.51
11.73
+4
7.63
-2.480
Amidation
L
Amphipathic
Linear
Stearylation
N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Assay & Model

A549 tumor bearing xenograft six-week-old male BALB/c nude mice
A549 tumor bearing xenograft six-week-old male BALB/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Cy-3 labeled siRNA
Cytosol and around Nucleus
Uptake efficiency of the STR-HK/siRNA complexes at MR 40 was approximately 20% higher than that of the lipo2000/siRNA and also improved uptake efficiency compared to STR-H0 K/siRNA.
Endocytosis
In vitro and in vivo
CCCSCCC
Additional Detail Fields 1 fields
CCCSCCC