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Peptide record

TPDB92920

NF70(H52) Cell-penetrating Peptides modified_plain modified
23 amino acids
Basic Information
3D PDB MODEL
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TPDB92920
NF70(H52)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 23-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticles N-terminal: Fatty Acid(C20)
Sequence
HHHHYHHGOILLKALKALAKAIL
Physicochemical Analysis
C119H189N37O24
RNDCEQMFPSTWV
H
2522.04
10.46
9
0
12
+4
3.70
0.113
136.09
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
59.08
1
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
6
H
2
I
5
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 6 I: 2 L: 5 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C119H189N37O24
2522.04
10.46
+4
3.70
0.113
Free
Nanoparticles
Modified
Linear
Fatty Acid(C20)
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Pluc 705 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
Synthetic
Cy5-labeled SCO-708
Inefficient at the transfection of SCO in HeLa pLuc 705 cells, with increasing luminescence less than 6-fold, compared to untreated control
In vitro