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Peptide record

TPDB92900

H16 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB92900
H16
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with TAMRA
Sequence
HHHHHHHHHHHHHHHH-NH2
Physicochemical Analysis
C96H114N48O17
ARNDCEQGILKMFPSTWYV
H
2212.27
8.46
16
0
0
+1
15.36
-3.200
0.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
16
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 16 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C96H114N48O17
2212.27
8.46
+1
15.36
-3.200
Amidation
L
Linear
Conjugated with TAMRA
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hepg2 Cells, Rerf-Lc-Ai And Ht1080 Cells

Assay & Model

HT1080 tumor cell bearing BALB/cAJcl-nu/nu mice (4 weeks)
HT1080 tumor cell bearing BALB/cAJcl-nu/nu mice (4 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
TAMRA dye , PAD and GFP protein
Lysosome And Golgi Appratus
H16 peptide showed a 5.45-fold (at pH 6.0) and a 5.36-fold (at pH 7.4) higher cellular uptake than R8 in HepG2 cells and 10.98 and 14.35-fold higher capacities against the RERF-LC-AI and the HT1080 cells, respectively
Macropinocytosis
In vitro and in vivo
CCCCCTTSCSSCTTCC
Additional Detail Fields 1 fields
CCCCCTTSCSSCTTCC