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Peptide record

TPDB92887

C12-H5-S4(13)-PV Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB92887
C12-H5-S4(13)-PV
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Laurylation
Sequence
HHHHHALWKTLLKKVLKAPKKKRKVC-NH2
Physicochemical Analysis
C147H246N48O28S1
NDEQGIMFSY
K
3165.94
11.32
14
0
9
+9
9.59
-0.969
90.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5500
173.72
2
Residue Composition
number
2
A
1
R
0
N
0
D
1
C
0
E
0
Q
0
G
5
H
0
I
4
L
8
K
0
M
0
F
1
P
0
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 5 I: 0 L: 4 K: 8 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C147H246N48O28S1
3165.94
11.32
+9
9.59
-0.969
Amidation
L
Linear
Laurylation
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 Or U87-Gfp Cells Nhas Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FAM-labeled siRNAs nanoparticles
Percentage of siRNA-positive NHAs was 78% and the GMFI increased 6.9-fold with respect to non-treated cells.H5-S413-PV-C12 and C12-H5-S413-PV were able to maintain essentially the the same percentage of siRNA-positive cells upon delivery of FAM-labeled siRNAs (94%) in the presence of serum in U87 cells
Endocytosis
In vitro
CHHHHHHHHHTTCCSSSCCCC
Additional Detail Fields 1 fields
CHHHHHHHHHTTCCSSSCCCC