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Peptide record

TPDB92885

gH625 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB92885
gH625
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: PEGylated superparamagnetic iron oxide nanoparticles (SPION) N-terminal: Acetylation
Sequence
Ac-HGLASTLTRWAHYNALIRAFC-NH2
Physicochemical Analysis
C109H165N33O27S1
DEQKMPV
A
2401.77
9.90
4
0
11
+2
-2.45
0.224
93.33
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
6990
291.03
6
Residue Composition
number
4
A
2
R
1
N
0
D
1
C
0
E
0
Q
1
G
2
H
1
I
3
L
0
K
0
M
1
F
0
P
1
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 2 I: 1 L: 3 K: 0 M: 0 F: 1 P: 0 S: 1 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
21
C109H165N33O27S1
2401.77
9.90
+2
-2.45
0.224
Amidation
PEGylated superparamagnetic iron oxide nanoparticles (SPION)
L
Linear
Acetylation
N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Cyanine 5.5 labelled anti-GFP siRNA (siGFP)
Cytoplasm
After 4 h of treatment with CS-MSN, all cells express cyanine 5.5 fluorescence, which indicates the quick internalization with high siRNA transfection efficiency (73 ± 3 %) of CS-MSN by MDA-MB-231 cancer cells.
In vitro
CCGGGGCC
Additional Detail Fields 1 fields
CCGGGGCC