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Peptide record

TPDB92883

HGDWT Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92883
HGDWT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: DTBTA-Eu3+ -labelled
Sequence
HGDWTKRWSFLA
Physicochemical Analysis
C71H98N20O17
NCEQIMPYV
W
1503.68
10.09
3
1
5
+1
-1.29
-0.867
40.83
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
11000
731.54
2
Residue Composition
number
1
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
1
H
0
I
1
L
1
K
0
M
1
F
0
P
1
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 1 K: 1 M: 0 F: 1 P: 0 S: 1 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C71H98N20O17
1503.68
10.09
+1
-1.29
-0.867
Free
DTBTA-Eu3+ -labelled
L
Linear
Free
N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

C57BL/6 mice (female, 8–10 weeks of age) were infected subcutaneously with S. aureus Cowan I
C57BL/6 mice (female, 8–10 weeks of age) were infected subcutaneously with S. aureus Cowan I

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
LST fused at C terminal
Significantly higher levels of LST_HGDWT (P = 0.033) and LST_SDSSD (P = 0.009) as compared to the parental LST were observed in bone
In vivo
CCCCCCCSSSCC
Additional Detail Fields 1 fields
CCCCCCCSSSCC