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Peptide record

TPDB92881

Tfr2 Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB92881
Tfr2
Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0 TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Blood-Brain Barrier, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: FAM is conjgated at the N-terminal
Sequence
HAIYPRH
Physicochemical Analysis
C41H60N14O9
NDCEQGLKMFSTWV
H
893.02
9.88
3
0
3
+1
1.76
-1.071
70.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
166.85
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
7
C41H60N14O9
893.02
9.88
+1
1.76
-1.071
Linear
FAM is conjgated at the N-terminal
Similarity
HisAlaIleTyrProArgHis
N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC1=CN=C-N1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

bEnd.3 cells

Assay & Model

Immunofluorescence microscopy
It shows the permeability towards the BBB.
Origin/Source

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
These novel peptide conjugates have the capacity to act as promising brain shuttles
Receptor-mediated transcytosis
Combined