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Peptide record

TPDB92878

HAI Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB92878
HAI
Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0 TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Blood-Brain Barrier, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: N-Methylated
Sequence
HAIYPRH-NH2
Physicochemical Analysis
C41H60N14O9
NDCEQGLKMFSTWV
H
893.02
9.88
3
0
3
+1
1.76
-1.071
70.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
166.85
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
7
C41H60N14O9
893.02
9.88
+1
1.76
-1.071
Amidation
L
Linear
N-Methylated
N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bbecs Or Rat Astrocytes And Intestine (Caco-2 Assay) And A Bbb Model

Assay & Model

Male Sprague Dawley rats (180–200 g)
Male Sprague Dawley rats (180–200 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
carboxyfuorescein (Cf) at N -terminal
HAI showed the best performance in the BBB model and crossed the intestinal barrier. AuNP-HAI showed greater penetration than AuNP-THR in-vivo.
Clathrin mediated endocytosis
In vitro and in vivo
CCSCCSCCCSSSSCCCSTTTCSTTTSCCC
Additional Detail Fields 1 fields
CCSCCSCCCSSSSCCCSTTTCSTTTSCCC