Back to search

Peptide record

TPDB92875

Cyt C 71-101 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92875
Cyt C 71-101
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: N-terminal acylation of peptide with 6-carboxy-tetramethylrhodamine
Sequence
GTKMIFVGIKKKEERADLIAYLKKA-NH2
Physicochemical Analysis
C131H224N34O34S1
NCQHPSW
K
2851.49
10.36
7
3
12
+4
7.39
-0.232
101.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
52.25
2
Residue Composition
number
3
A
1
R
0
N
1
D
0
C
2
E
0
Q
2
G
0
H
3
I
2
L
6
K
1
M
1
F
0
P
0
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 1 C: 0 E: 2 Q: 0 G: 2 H: 0 I: 3 L: 2 K: 6 M: 1 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
25
C131H224N34O34S1
2851.49
10.36
+4
7.39
-0.232
Amidation
L
Linear
N-terminal acylation of peptide with 6-carboxy-tetramethylrhodamine
NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U373MG cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (6-carboxy-tetramethylrhodamine)
Endoplasmic reticulum
High (105 fold uptake)
In vitro
CCSCCCCSSCCTTTTTHHHHHTTTC
Additional Detail Fields 1 fields
CCSCCCCSSCCTTTTTHHHHHTTTC