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Peptide record

TPDB92865

HIV-1 TAT (48–57)-PNA Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92865
HIV-1 TAT (48–57)-PNA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: PNAs via a flexible ethylene glycol linker (8-amino-3,6-dioxaoctanoic acid)
Sequence
GRKKRRQRRRYK
Physicochemical Analysis
C70H130N34O15
ANDCEHILMFPSTWV
R
1688.02
12.71
9
0
1
+9
7.48
-3.658
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
88.27
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C70H130N34O15
1688.02
12.71
+9
7.48
-3.658
Free
PNAs via a flexible ethylene glycol linker (8-amino-3,6-dioxaoctanoic acid)
L
Linear
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

S. Pneumoniae

Assay & Model

G. mellonella Larvae infected with S. pneumoniae
G. mellonella Larvae infected with S. pneumoniae

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
anti-gyrA PNA
(RXR)4XB-coupled antisense PNAs were more efficient than TAT-coupled antisense PNAs.
In vitro and in vivo
CCCCGGGTSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

S. Pneumoniae

Assay & Model

G. mellonella Larvae infected with S. pneumoniae
G. mellonella Larvae infected with S. pneumoniae

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
anti-rpoB PNA
(RXR)4XB-coupled antisense PNAs were more efficient than TAT-coupled antisense PNAs.
In vitro and in vivo
CCCCGGGTSSCC
Additional Detail Fields 1 fields
CCCCGGGTSSCC