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Peptide record

TPDB92863

TAT Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92863
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
Chemical: PHSRN peptide N-terminal: Phsrn-30G(-) Peptide
Sequence
GRKKRRQRRRPQ
Physicochemical Analysis
C65H124N34O15
ANDCEHILMFSTWYV
R
1621.92
13.10
8
0
0
+8
8.46
-3.650
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
2
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C65H124N34O15
1621.92
13.10
+8
8.46
-3.650
Free
PHSRN peptide
L
Cationic
Linear
Phsrn-30G(-) Peptide
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Oleosin micelles labelled with DyLight-488
After 15 hours, RGDS-30G(-)-Tat led to a 6.5 fold increase in cell uptake compared to the nonactive RADS control.
In vitro
CCCCGGGGGGGGGCCCCC
Additional Detail Fields 1 fields
CCCCGGGGGGGGGCCCCC