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Peptide record

TPDB92855

TAT Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB92855
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Metal ion chelating agent diethylenetriamine pentaacetate (DTPA)
Sequence
GRKKRRQRRRPPQGYG
Physicochemical Analysis
C83H146N38O20
ANDCEHILMFSTWV
R
1996.31
12.71
8
0
1
+8
7.99
-2.969
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
74.64
3
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
2
Q
3
G
0
H
0
I
0
L
2
K
0
M
0
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
16
C83H146N38O20
1996.31
12.71
+8
7.99
-2.969
Free
Metal ion chelating agent diethylenetriamine pentaacetate (DTPA)
L
Cationic
Linear
Free
N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

H1299 Cells

Assay & Model

Xenografts of H1299 cells, wild-type (WT) or stably transfected with H2B-EGFP of female BALB/c nu/nu mice
Xenografts of H1299 cells, wild-type (WT) or stably transfected with H2B-EGFP of female BALB/c nu/nu mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Phage Display
GFP-G1 mouse monoclonal antibody
111In-GFP-G1-TAT showed a 6.8-fold increase in cell uptake than non-TAT modified 111In-GFP-G1
In vitro and in vivo
CCCSSCCCCCC
Additional Detail Fields 1 fields
CCCSSCCCCCC