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Peptide record

TPDB92854

HIV-1 Tat (48-60) Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB92854
HIV-1 Tat (48-60)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with Alexa 488 at glycyl cysteine sequence
Sequence
GRKKRRQRRRPPQC
Physicochemical Analysis
C73H136N36O17S1
ANDEHILMFSTWYV
R
1822.17
12.71
8
0
0
+8
8.67
-3.064
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
2
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C73H136N36O17S1
1822.17
12.71
+8
8.67
-3.064
Conjugation with Alexa 488 at glycyl cysteine sequence
L
Cationic
Linear
Free
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1, HeLa and Jurkat

Source & Reference

CPPsite3.0
CPPsite3
US 20040132970

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (Alexa-488)
Only punctate distribution (vesicles)
Endocytic pathway (Macropinocytosis)
In vitro
CCCCCCCCCCCSCC
Additional Detail Fields 1 fields
CCCCCCCCCCCSCC